More than 100 neurologic diseases injuries and intoxications are known to prominently or exclusively involve the white matter of the brain12 without exception these disorders have the potential to disrupt aspects of cognitive and emotional function and to lead to important syndromes related to white matter dysfunction. 1 neurology 1998 jun5061535 40 the behavioral neurology of cerebral white matter filley cm1 author information 1department of neurology university of colorado school of medicine denver veterans affairs medical center usa behavioral neurology has primarily focused on brain behavior relations as revealed by disorders of the cerebral cortex and subcortical gray matter. White matter comprises nearly half the brain volume and plays a key role in development aging and many neurologic and psychiatric disorders across the life span more than 100 disorders exist in which white matter neuropathology is the primary or a prominent feature. Behavioral neurology is founded on lesions of cortical gray matter but recently the contributions of cerebral white matter to cognitive and emotional dysfunction have also attracted attention the behavioral neurology of white matter surveys this broad and fascinating field from a clinical perspective. Get this from a library the behavioral neurology of white matter christopher m filley this text examines the role of the brains white matter in the organization of human mental function the white matter is discussed as an important complement to cortical and subcortical gray matter
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